Lactobacillus acidophilus slam_laa02

Intervention

1 paper5 findings

  • 1 lab in 1 country
  • Funders: Ministry of Education and 1 more
  • Animals1

Outcomes

4

SNCA

downin mice1downin worms1

1 study
  1. Lactobacillus acidophilus slam_laa02 decreases SNCA in mice.

    “These changes were accompanied by a notable reduction in α-synuclein expression”

    Animalsin a rotenone-induced mouse model

    A neuroprotective effect of newly isolated probiotic bacterium Lactobacillus acidophilus SLAM_LAA02 in a rotenone-induced mouse model of Parkinson's disease

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie12 Dec 2025

  2. Lactobacillus acidophilus slam_laa02 decreases SNCA in worms.

    “reduced α-synuclein expression in transgenic worms”

    Model organismsin transgenic worms

    A neuroprotective effect of newly isolated probiotic bacterium Lactobacillus acidophilus SLAM_LAA02 in a rotenone-induced mouse model of Parkinson's disease

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie12 Dec 2025

More on SNCA

BDNF

upin mice1

1 study
  1. Lactobacillus acidophilus slam_laa02 increases BDNF in mice.

    “upregulated neuroprotective gene expression, including brain-derived neurotrophic factor (BDNF)”

    Animalsin a rotenone-induced mouse model

    A neuroprotective effect of newly isolated probiotic bacterium Lactobacillus acidophilus SLAM_LAA02 in a rotenone-induced mouse model of Parkinson's disease

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie12 Dec 2025

More on BDNF

Motor function

upin mice1

1 study
  1. Lactobacillus acidophilus slam_laa02 improves motor function in mice.

    “L. acidophilus SLAM_LAA02 administration ameliorated motor dysfunction”

    Animalsin a rotenone-induced mouse model

    A neuroprotective effect of newly isolated probiotic bacterium Lactobacillus acidophilus SLAM_LAA02 in a rotenone-induced mouse model of Parkinson's disease

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie12 Dec 2025

Lifespan

upin worms1

1 study
  1. Lactobacillus acidophilus slam_laa02 extends lifespan in worms.

    “supplementation extended lifespan, enhanced antimicrobial defense, improved behavioral responses, and reduced α-synuclein expression in transgenic worms”

    Model organismsin transgenic worms

    A neuroprotective effect of newly isolated probiotic bacterium Lactobacillus acidophilus SLAM_LAA02 in a rotenone-induced mouse model of Parkinson's disease

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie12 Dec 2025

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