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KU-55933

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Medical Center, University of Rochester and 4 more
  • Animals1

Outcomes

2

Cellular senescence

downin mouse cells1

1 study

  1. KU-55933 decreases cellular senescence in mouse cells.

    “inhibiting ATM activation with KU-55933 restored DNA repair in G2/M phase and attenuated senescence in chronic cellular model of FECD lacking NQO1”

    Cellsin chronic cellular model of FECD lacking NQO1

    Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs endothelial corneal dystrophy

    Communications biologyNov 10, 2024

More on Cellular senescence

DNA repair

upin mouse cells1

1 study

  1. KU-55933 increases DNA repair in mouse cells.

    “inhibiting ATM activation with KU-55933 restored DNA repair in G2/M phase”

    Cellsin chronic cellular model of FECD lacking NQO1

    Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs endothelial corneal dystrophy

    Communications biologyNov 10, 2024

More on DNA repair

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