AgingResearch.NewsJoin free

KDS12025

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Institute for Basic Science and 1 more
  • Animals1

Outcomes

3

Hydrogen peroxide

downin cells1

1 study

  1. KDS12025 decreases hydrogen peroxide in cells.

    “KDS12025 reduces astrocytic H2O2, alleviates astrogliosis, normalizes Hb, and reverts to a virtuous cycle of redox balance”

    Cellsastrocytes

    Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases

    Signal transduction and targeted therapy22 Aug 2025

More on Hydrogen peroxide

Motor function

upin animals1

1 study

  1. KDS12025 improves motor function.

    “improves motor function even in severe amyotrophic lateral sclerosis and aging.”

    Animalssevere amyotrophic lateral sclerosis and aging

    Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases

    Signal transduction and targeted therapy22 Aug 2025

Lifespan

upin animals1

1 study

  1. KDS12025 extends lifespan.

    “KDS12025 extends survival and improves motor function even in severe amyotrophic lateral sclerosis and aging.”

    Animalssevere amyotrophic lateral sclerosis and aging

    Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases

    Signal transduction and targeted therapy22 Aug 2025

Upstream

1

hemoglobin

is required forin animals1

1 study

  1. hemoglobin is required for KDS12025.

    “Gene silencing of Hb abrogates the impact of KDS12025 in both culture and animal models, confirming the necessity of Hb for the effects of KDS12025.”

    Animalsshown by gene silencing in culture and animal models

    Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases

    Signal transduction and targeted therapy22 Aug 2025

More on hemoglobin

Latest

Related