Jund gene therapy

1. Jund gene therapy increases HMGB1 in mice.

   “injection of JunD-expressing viral vectors in astrocytes increased their proliferation and HMGB1 levels in the aged brain”

   AnimalsJunD-expressing viral vectorsastrocyte

   Comprehensive single cell profiling of ageing glial cells reveals impaired Wnt signalling and Jun transcription factors regulating cortical astrocytes

   bioRxiv (Cold Spring Harbor Laboratory)·17 Apr 2026Preprint

More on HMGB1

1. Jund gene therapy increases astrocyte proliferation in mice.

   “Overexpression of JunD increases proliferation after mild injury in aged astrocytes.”

   Animalsafter mild injuryJunD-expressing viral vectorsastrocyte

   Comprehensive single cell profiling of ageing glial cells reveals impaired Wnt signalling and Jun transcription factors regulating cortical astrocytes

   bioRxiv (Cold Spring Harbor Laboratory)·17 Apr 2026Preprint