Isrib

1 paper1 finding

Outcomes

1

protein synthesis

upin reviews1

1 study

Isrib improves protein synthesis.
“ISRIB is a prototype small molecule that activates eIF2B and restores translation homeostasis”
Reviewin aging and neurodegenerative conditions
ISRIB as a prototype eIF2B activator: Pharmacology, mechanisms, and translational potential in aging-related cognitive disorders
Pharmacological research5 May 2026

Latest

2 in 12 months

Journal of Alzheimer's Disease21 May

An aging hallmark, Alzheimer's disease, and APOE nexus

Experiments in human cellsAPOE

Pharmacological Research8 May

ISRIB as a prototype eIF2B activator: Pharmacology, mechanisms, and translational potential in aging-related cognitive disorders

ReviewInterventions

bioRxiv27 May

eIF2α phosphorylation evokes dystonia-like movements with D2-receptor and cholinergic origin and abnormal neuronal connectivity

Preprint: experiments in model organismsMechanisms

Ecotoxicology and Environmental Safety31 Aug

ISRIB inhibits the senescence of type II pulmonary epithelial cells to alleviate pulmonary fibrosis induced by silica in mice

Experiments in animalsMechanisms

Biochemical and Biophysical Research Communications3 Jul

ISRIB alleviates aging-associated brown fat UCP1 translational repression and thermogenic deficiency

Experiments in animalsInterventions