Iron overload

1. Iron overload inhibits oxidative phosphorylation in mice.

   “decreased mitochondrial membrane potential and ATP levels”

   Animalsneutrophil

   Iron overload impairs mitochondrial function, induces neutrophil aging, inhibits its bactericidal ability, and exacerbates mouse peritonitis

   Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·Sep 1, 2024

More on Oxidative phosphorylation

1. Iron overload induces cellular senescence in mice.

   “aggravated aging in neutrophils (indicated by increased expression of P16 and a higher number of SA-β-Gal positive cells)”

   Animalsneutrophil

   Iron overload impairs mitochondrial function, induces neutrophil aging, inhibits its bactericidal ability, and exacerbates mouse peritonitis

   Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·Sep 1, 2024

More on Cellular senescence

1. Iron overload impairs bactericidal ability in mice.

   “significantly reduced bactericidal ability of neutrophil”

   Animalsneutrophil

   Iron overload impairs mitochondrial function, induces neutrophil aging, inhibits its bactericidal ability, and exacerbates mouse peritonitis

   Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·Sep 1, 2024

1. Iron overload shortens lifespan in mice.

   “a shorter survival time”

   Animalsin E. coli-induced peritonitis

   Iron overload impairs mitochondrial function, induces neutrophil aging, inhibits its bactericidal ability, and exacerbates mouse peritonitis

   Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·Sep 1, 2024