Iron chelators

1. Iron chelators have no effect on inflammation in mice.

   “Importantly, inflammatory markers, such as ionized calcium-binding adapter molecule 1 (Iba1) and glial fibrillary acidic protein (GFAP), were not elevated by treatment.”

   Animals8-week

   Pseudohypoxia induced by iron chelators preserves working memory performance in aged mice

   Scientific reports·2 Mar 2026

More on Inflammation

1. Iron chelators increase white blood cell count in mice.

   “White blood cell counts and hippocampal volume, as assessed by magnetic resonance imaging (MRI), were elevated in the treatment groups relative to controls.”

   Animals8-week

   Pseudohypoxia induced by iron chelators preserves working memory performance in aged mice

   Scientific reports·2 Mar 2026

More on White blood cell count

1. Iron chelators increase hippocampal volume in mice.

   “White blood cell counts and hippocampal volume, as assessed by magnetic resonance imaging (MRI), were elevated in the treatment groups relative to controls.”

   Animals8-week

   Pseudohypoxia induced by iron chelators preserves working memory performance in aged mice

   Scientific reports·2 Mar 2026

1. Iron chelators decrease hydroxyl radical in human cells.

   “aged NHDFs that already showed a higher concentration of intracellular Fe2+ and stronger hydroxyl radical signals than young NHDFs also elicited a reduction in these levels after the addition of an iron chelator”

   Cellsin senescent NHDFs

   Iron Chelation Reduces Intracellular Hydroxyl Radicals in Normal Human Dermal Fibroblasts Independently of Aging

   Antioxidants (Basel, Switzerland)·28 Nov 2025

More on Hydroxyl radical

1. Iron chelators decrease lipid droplet formation in cells.

   “Chelating labile iron or scavenging ROS suppresses LD formation.”

   Cellsiron-driven

   Labile iron overload reprograms microglia and neurons for lipid droplet synthesis in the aging brain

   bioRxiv : the preprint server for biology·5 Nov 2025Preprint