INTERLEUKIN-21

2 papers4 findings

MeSH D000098546

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: Japan Society for the Promotion of Science

Animals2

Outcomes

4

Immune response

downin mice1

1 study

INTERLEUKIN-21 impairs immune response in mice.
“IL-21 exposure resulted in impaired antiviral responses, characterized by reduced MHC-II expression on macrophages and diminished IFN-α production in response to viral challenges.”
Animalsin response to viral challengeslung
Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases
Cellular and molecular life sciences : CMLS14 Feb 2026

More on Immune response

Cellular senescence

upin mice1

1 study

INTERLEUKIN-21 induces cellular senescence in mice.
“IL-21 exposure also promoted cellular senescence, evidenced by upregulation of senescence-associated genes and increased frequencies of KLRG1-positive T cells.”
Animalslung
Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases
Cellular and molecular life sciences : CMLS14 Feb 2026

More on Cellular senescence

Inflammation

upin mice1

1 study

INTERLEUKIN-21 increases inflammation in mice.
“IL-21 induces a pro-inflammatory state in the lungs, characterized by increased levels of key inflammatory cytokines”
Animalslung
Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases
Cellular and molecular life sciences : CMLS14 Feb 2026

More on Inflammation

TBX21

upin mice1

1 study

INTERLEUKIN-21 increases TBX21 in mice.
“This combination of IL-21 and IFN-γ upregulated T-bet expression on B cells in SjD model mice.”
Animalsin SjD model micesalivary glands
Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease
Journal of immunology research1 Jan 2026

Latest

2 in 12 months

Journal of Immunology Research24 Mar

Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease

Experiments in miceBlood and immune system

Cellular and Molecular Life Sciences15 Feb

Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases

Experiments in miceLung