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Integrated diabetes care

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Human trial1

Outcomes

4

SGLT2 inhibitors

upin humans1

1 study

  1. Integrated diabetes care increases SGLT2 inhibitors in humans (doubled).

    “Utilization of SGLT-2is and incretin analogs doubled”

    Human trialserious mental illness and diabetes mellitus6-12 monthsn = 68

    Integrated Diabetes Care Improves Metabolic Outcomes and Promotes Utilization of Incretin Analogs and Sodium–Glucose Cotransporter Type 2 Inhibitors in Patients with Serious Mental Illness

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on SGLT2 inhibitors

Incretin analogs

upin humans1

1 study

  1. Integrated diabetes care increases incretin analogs in humans (doubled).

    “Utilization of SGLT-2is and incretin analogs doubled”

    Human trialserious mental illness and diabetes mellitus6-12 monthsn = 68

    Integrated Diabetes Care Improves Metabolic Outcomes and Promotes Utilization of Incretin Analogs and Sodium–Glucose Cotransporter Type 2 Inhibitors in Patients with Serious Mental Illness

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Incretin analogs

Body weight

downin humans1

1 study

  1. Integrated diabetes care decreases body weight in humans (-2.4 kg, p=0.3).

    “2.4 kg weight loss (p=0.3)”

    Human trialserious mental illness and diabetes mellitus6-12 monthsn = 68

    Integrated Diabetes Care Improves Metabolic Outcomes and Promotes Utilization of Incretin Analogs and Sodium–Glucose Cotransporter Type 2 Inhibitors in Patients with Serious Mental Illness

    ADA Scientific Sessions 2025 abstract13 Jun 2025

HbA1c

downin humans1

1 study

  1. Integrated diabetes care decreases HbA1c in humans (-1.1% HbA1c, p=0.001).

    “Patients achieved a 1.1% HbA1c reduction (p=0.001)”

    Human trialserious mental illness and diabetes mellitus6-12 monthsn = 68

    Integrated Diabetes Care Improves Metabolic Outcomes and Promotes Utilization of Incretin Analogs and Sodium–Glucose Cotransporter Type 2 Inhibitors in Patients with Serious Mental Illness

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on HbA1c

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