Integrated care for older people

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: Shandong Academy of Agricultural Sciences

Human trial1
Humans1

Outcomes

Depressive symptoms

downin humans1

1 study

Integrated care for older people decreases depressive symptoms in humans (least-squares mean difference (control-intervention) 0.09, 95% CI 0.03 to 0.14).
“psychological health by 5-item Geriatric Depression Scale (0.09, 95% CI, 0.03–0.14)”
Human trial6 monthsn = 938
Implementation and Impact of the WHO Integrated Care for Older People Program in Older Adults With Frailty in China
GSA 2025 abstract31 Dec 2025