INHBE-3
1 paper4 findings
- 1 lab
- Animals1
Outcomes
4Fibrosis
downin mice1−58%
1 study
Fibrosis
downin mice1−58%
INHBE-3 decreases fibrosis in mice (-58%).
“reductions in total (41%) and pro-inflammatory (80%) macrophages and fibrosis (58%) were observed in visceral fat.”
Animalsdiet-induced obesityGalNAc-conjugated siRNAvisceral fat56 days
Silencing Hepatokine Activin E Promotes a Healthy Body Composition and Metabolic Profile in Mice
ADA Scientific Sessions 2026 abstract5 Jun 2026
Muscle mass
no changein mice1
1 study
Muscle mass
no changein mice1
INHBE-3 has no effect on muscle mass in mice.
“There was no statistically significant change in quadricep muscle mass.”
Animalsdiet-induced obesityGalNAc-conjugated siRNAquadricep muscle28 days
Silencing Hepatokine Activin E Promotes a Healthy Body Composition and Metabolic Profile in Mice
ADA Scientific Sessions 2026 abstract5 Jun 2026
Visceral fat mass
downin mice1−40%
1 study
Visceral fat mass
downin mice1−40%
INHBE-3 decreases visceral fat mass in mice (-40%).
“with a 40% reduction in visceral fat mass and 43% less adipocyte hypertrophy.”
Animalsdiet-induced obesityGalNAc-conjugated siRNAvisceral fat28 days
Silencing Hepatokine Activin E Promotes a Healthy Body Composition and Metabolic Profile in Mice
ADA Scientific Sessions 2026 abstract5 Jun 2026
Body weight
downin mice1−9%
1 study
Body weight
downin mice1−9%
INHBE-3 decreases body weight in mice (-9%).
“At day 28, INHBE-3 treated mice weighed 9% less than controls, with a 40% reduction in visceral fat mass and 43% less adipocyte hypertrophy.”
Animalsdiet-induced obesityGalNAc-conjugated siRNA28 days
Silencing Hepatokine Activin E Promotes a Healthy Body Composition and Metabolic Profile in Mice
ADA Scientific Sessions 2026 abstract5 Jun 2026