Inflammation
Inflammation has been studied in 2 papers since 2019: 1 observational study in people, 1 review. The newest paper, Jun 15, 2021: “Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection”.
See all 2 papers on inflammation
At a glance
The findings reach people, from one lab or study. 3 independent labs in 3 countries.
“A significant and decreasing linear trend in telomere length was found as CRP levels increased in men, regardless of the depression status”
1 of its findings points the other way.
- 3 independent labs in 3 countries
- 1 finding against
- Funders: UKRI | Medical Research Council and others
- 1 of 7 findings with company ties
- Humans1
What did studies of inflammation find?
5Studies of inflammation measured 5 outcomes; the most studied are biological age (1 study), hematopoietic stem cell self-renewal (1) and hematopoietic stem cell function (1).
Biological age
upin mice1
1 study
Biological age
upin mice1
Inflammation increases biological age in mice.
“HSCs from challenged mice demonstrated multiple cellular and molecular features of accelerated aging”
Animals
Cell stem cell
Hematopoietic stem cell self-renewal
downin mice1
1 study
Hematopoietic stem cell self-renewal
downin mice1
Inflammation decreases hematopoietic stem cell self-renewal in mice.
“In vivo HSC self-renewal divisions were absent or extremely rare during both challenge and recovery periods.”
Animals
Cell stem cell
Hematopoietic stem cell function
downin mice1
1 study
Hematopoietic stem cell function
downin mice1
Inflammation impairs hematopoietic stem cell function in mice.
“we observed an irreversible depletion of functional HSCs following challenge with inflammation or bacterial infection, with no evidence of any recovery up to 1 year afterward.”
Animalsup to 1 year afterward
Cell stem cell
YTHDF2EXPRESSION
upin mice1
1 study
YTHDF2EXPRESSION
upin mice1
Inflammation increases YTHDF2EXPRESSION in mice (experimentally induced).
“Experimentally induced inflammation increases YTHDF2 expression”
Animalsexperimentally induced
The Journal of experimental medicine
Telomere length
no changein humans1
1 study
Telomere length
no changein humans1
Inflammation was not clearly linked with telomere length in humans (regardless of depression status).
“In women, there was no association between CRP and telomere length, regardless of the depression status.”
Humansregardless of depression statusfemales
Effects of Inflammation and Depression on Telomere Length in Young Adults in the United States
Journal of clinical medicine
What is inflammation linked with?
2Studies link inflammation with 2 measures, most often shortened telomere length (1 study) and telomere length (1).
Shortened telomere length
upin humans1OR 1.77
1 study
Shortened telomere length
upin humans1OR 1.77
Inflammation is associated with shortened telomere length in humans (men without depression; adjusted for covariates) (adjusted OR 1.77, 95% CI 1.09-2.90).
“Among men without depression, those with an elevated CRP level had increased odds of having a shortened telomere length”
Humansmen without depression; adjusted for covariatesmales
Effects of Inflammation and Depression on Telomere Length in Young Adults in the United States
Journal of clinical medicine
Telomere length
downin humans1
1 study
Telomere length
downin humans1
Inflammation is associated with telomere length in humans (regardless of depression status) (significant linear trend, p < 0.05).
“A significant and decreasing linear trend in telomere length was found as CRP levels increased in men, regardless of the depression status”
Humansregardless of depression statusmales
Effects of Inflammation and Depression on Telomere Length in Young Adults in the United States
Journal of clinical medicine