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In vitro aging

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Animals1

Outcomes

2

CRMP2 dimers and higher-mass oligomers

upin mouse cells1

1 study

  1. In vitro aging increases CRMP2 dimers and higher-mass oligomers in mouse cells.

    “and also induced a progressive accumulation of apparent dimers and higher-mass oligomers as judged by SDS-PAGE.”

    Cellscell-free in vitro aging at pH 7.4 and 37°Cpurified recombinant mouse CRMP20–28 days

    Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline

    Research square14 Nov 2024Preprint

More on CRMP2 dimers and higher-mass oligomers

CRMP2 isoaspartyl sites

upin mouse cells1

1 study

  1. In vitro aging increases CRMP2 isoaspartyl sites in mouse cells.

    “In vitro aging of rCRMP2 at pH 7.4, 37°C for 0-28 days led to robust accumulation of isoAsp sites that were repairable by PIMT”

    Cellscell-free in vitro aging at pH 7.4 and 37°Cpurified recombinant mouse CRMP20–28 days

    Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline

    Research square14 Nov 2024Preprint

More on CRMP2 isoaspartyl sites

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