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Iclnp@sf

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: China Postdoctoral Science Foundation and 2 more
  • Animals1

Outcomes

2

New bone formation

upin mice1+40%

1 study

  1. Iclnp@sf increases new bone formation in mice (≈40%).

    “while Runx2 mRNA delivery raised new bone formation (BV/TV) to ≈40% in defect models, both markedly outperforming conventional LNPs”

    Animalsdelivery of Runx2 mRNA in defect modelsbone

    Ionizable Coenzyme-Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases

    Advanced materials (Deerfield Beach, Fla.)8 Oct 2025

Hair follicle density

upin mice1+50%

1 study

  1. Iclnp@sf increases hair follicle density in mice (≈50%).

    “iCLNP@SF delivery of Gas6 mRNA increased hair follicle density by ≈50% in an androgenetic alopecia mouse model”

    Animalsdelivery of Gas6 mRNA in androgenetic alopecia modelskin

    Ionizable Coenzyme-Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases

    Advanced materials (Deerfield Beach, Fla.)8 Oct 2025

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