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Human umbilical cord mesenchymal stem cell extracellular vesicles

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funder: Instituto de Salud Carlos III
  • Animals1

Outcomes

1

Pulmonary fibrosis

no changein animal1downin animal1

1 study

  1. Human umbilical cord mesenchymal stem cell extracellular vesicles have no effect on pulmonary fibrosis in animal.

    “antifibrotic effects were observed only when EVs were administered prophylactically, before the establishment of fibrosis.”

    Animalstherapeutic administration in established fibrosis in aged modelslung

    EVs Biodistribution and Antifibrotic Impact in Aged Lung Fibrosis Model

    BioFactors (Oxford, England)1 Jan 2025

  2. Human umbilical cord mesenchymal stem cell extracellular vesicles decrease pulmonary fibrosis in animal.

    “IV-administered EVs reduced fibrotic mRNA biomarkers, collagen deposition, inflammatory cell infiltration, and macrophage polarization in BAL, as well as altering cytokine.”

    Animalsprophylactic IV administration in aged lung fibrosis modellung

    EVs Biodistribution and Antifibrotic Impact in Aged Lung Fibrosis Model

    BioFactors (Oxford, England)1 Jan 2025

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