Human plasma-derived enampt-containing extracellular vesicles

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Japan Society for the Promotion of Science and 2 more

Animals1

Outcomes

NPY

downin mice1

1 study

Human plasma-derived enampt-containing extracellular vesicles decrease NPY in mice.
“eNAMPT-EV administration led to an increase in body temperature and suppression of hypothalamic Npy gene expression.”
Animalshypothalamus
Human plasma-derived eNAMPT-containing extracellular vesicles promote NAD⁺ biosynthesis and thermogenesis in mice
npj aging24 Nov 2025

Latest

1 in 12 months

npj Aging25 Nov