Human neural progenitor cells
3 papers9 findings
- 2 independent labs in 2 countries
- 8 of 9 findings with company ties
- Animals3
Outcomes
8Purkinje neuron survival
upin rats1
1 study
Purkinje neuron survival
upin rats1
Human neural progenitor cells increase purkinje neuron survival in rats.
“live NPC-treated mutants had significantly more surviving Purkinje neurons compared to mutants that were untreated or received dead NPCs.”
Animalsin spastic Han Wistar mutant ratslive NPCscerebellum500,000 live NPCs
Cell transplantation1 Jan 2020
Rotarod performance
upin rats1
1 study
Rotarod performance
upin rats1
Human neural progenitor cells improve rotarod performance in rats.
“Similar improvements were observed during rotarod testing and weight gain through the completion of the experiments (100 d).”
Animalsin spastic Han Wistar mutant ratslive NPCscerebellum500,000 live NPCsthrough 100 d
Cell transplantation1 Jan 2020
Open field activity
upin rats1
1 study
Open field activity
upin rats1
Human neural progenitor cells improve open field activity in rats.
“However, at day 45, the live NPC-treated mutants exhibited significant improvements in open field activity.”
Animalsin spastic Han Wistar mutant ratslive NPCscerebellum500,000 live NPCs
Cell transplantation1 Jan 2020
Longevity
upin rats1
1 study
Longevity
upin rats1
Human neural progenitor cells extend lifespan longevity in rats.
“Transplanted Human Neural Progenitor Cells Attenuate Motor Dysfunction and Lengthen Longevity in a Rat Model of Ataxia”
Animalsin spastic Han Wistar mutant ratslive NPCscerebellum500,000 live NPCsthrough 100 d
Cell transplantation1 Jan 2020
Body weight
upin rats1
1 study
Body weight
upin rats1
Human neural progenitor cells increase body weight in rats.
“displayed significantly higher motor activity scores and sustained greater weights and longevities than control-treated sHW rats”
Animalsin spastic Han-Wistar mutant ratscerebellar cortex500,000 cells in 5 μL mediamales
Cell transplantation1 Nov 2017
Lifespan
upin rats1
1 study
Lifespan
upin rats1
Human neural progenitor cells extend lifespan in rats.
“displayed significantly higher motor activity scores and sustained greater weights and longevities than control-treated sHW rats”
Animalsin spastic Han-Wistar mutant ratscerebellar cortex500,000 cells in 5 μL mediamales
Cell transplantation1 Nov 2017
Motor activity
upin rats1
1 study
Motor activity
upin rats1
Human neural progenitor cells improve motor activity in rats.
“displayed significantly higher motor activity scores and sustained greater weights and longevities than control-treated sHW rats”
Animalsin spastic Han-Wistar mutant ratscerebellar cortex500,000 cells in 5 μL mediamales
Cell transplantation1 Nov 2017
Motor performance
no changein mice1
1 study
Motor performance
no changein mice1
Human neural progenitor cells have no effect on motor performance in mice.
“improvement in motor performance and extension of lifespan were not observed in all hNP transplantation groups compared to vehicle-injected controls.”
AnimalsSOD1(G93A) transgenic mice
Experimental & molecular medicine31 Jul 2009
Associations
1Ataxia
downin rats1
1 study
Ataxia
downin rats1
Human neural progenitor cells lower the risk of ataxia in rats.
“implanted human progenitor cells reduced the ataxic symptoms in the sHW rat”
Animalsin spastic Han-Wistar mutant rats
Cell transplantation1 Nov 2017