Human neural progenitor cells expressing gdnf

Human neural progenitor cells expressing gdnf shortens lifespan in mice.

“lifespan of GDNF-expressing hNP recipient mice by lentiviral vector was shortened compared to controls, which was largely due to the decreased survival times of female animals.”

AnimalsSOD1(G93A) transgenic micefemales

Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice

Experimental & molecular medicine·31 Jul 2009

Human neural progenitor cells expressing gdnf decreases loss of motor neurons in mice.

“Transplantation of GDNF- or IGF-1-expressing hNPs attenuated the loss of motor neurons”

AnimalsSOD1(G93A) transgenic micespinal cord

Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice

Experimental & molecular medicine·31 Jul 2009