Human activated protein c

1. Human activated protein c decreases CD62P-positive platelet frequency in human cells (Fold change 1.5 ± 0.03 versus 1.8 ± 0.07; p = 0.01).

   “Fold change in frequency of activated (CD62P+) platelets in channel effluent was significantly decreased in association with GTKO+hAPC”

   CellsGTKO endothelial-cell pretreatment compared with GT/DKO ± hCD55 endothelial cellschannel effluentn = 6

   Expression of Human Thrombomodulin by Porcine Endothelium Attenuates Thrombus Formation and Platelet Activation in a Dynamic Shear Flow Model

   Xenotransplantation·1 Jan 2026

More on CD62P-positive platelet frequency

1. Human activated protein c decreases platelet adhesion and aggregation in human cells.

   “aggregation (fluorescence intensity) were significantly reduced in association with human APC (hAPC) pretreatment of GTKO”

   CellsPretreatment of GTKO endothelial cells before human whole-blood perfusion; compared with GT/DKO ± hCD55 endothelial cellsporcine aortic endothelium

   Expression of Human Thrombomodulin by Porcine Endothelium Attenuates Thrombus Formation and Platelet Activation in a Dynamic Shear Flow Model

   Xenotransplantation·1 Jan 2026