CD62P-positive platelet frequency

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Interventions

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Human activated protein c

downin human cells1

1 study

Human activated protein c decreases CD62P-positive platelet frequency in human cells (Fold change 1.5 ± 0.03 versus 1.8 ± 0.07; p = 0.01).
“Fold change in frequency of activated (CD62P+) platelets in channel effluent was significantly decreased in association with GTKO+hAPC”
CellsGTKO endothelial-cell pretreatment compared with GT/DKO ± hCD55 endothelial cellschannel effluentn = 6
Expression of Human Thrombomodulin by Porcine Endothelium Attenuates Thrombus Formation and Platelet Activation in a Dynamic Shear Flow Model
Xenotransplantation1 Jan 2026

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Upstream

1

THBD

downin human cells1

1 study

THBD decreases CD62P-positive platelet frequency in human cells (Fold change 1.6 ± 0.03 versus 1.8 ± 0.07; p = 0.02).
“and DKO.hCD55.hTBM (1.6 ± 0.03 p = 0.02, n = 12) or 10-GE ECs (1.3 ± 0.04 p < 0.0001, n = 9)”
CellsDKO.hCD55.hTBM endothelial cells compared with GT/DKO ± hCD55 endothelial cellschannel effluentn = 12
Expression of Human Thrombomodulin by Porcine Endothelium Attenuates Thrombus Formation and Platelet Activation in a Dynamic Shear Flow Model
Xenotransplantation1 Jan 2026

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Xenotransplantation15 Oct

Expression of Human Thrombomodulin by Porcine Endothelium Attenuates Thrombus Formation and Platelet Activation in a Dynamic Shear Flow Model

Experiments in pig cellsThrombosis