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Hsa-mirvana MIR-146A inhibitor

Intervention

3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 3 of 3 findings with company ties

Outcomes

3

DNA damage response

upin human cells1

1 study

  1. Hsa-mirvana MIR-146A inhibitor increases DNA damage response in human cells.

    “an increase in DNA damage and pro-inflammatory markers”

    Cellsin NHDFsskin

    miR-146a is a critical target associated with multiple biological pathways of skin aging

    Frontiers in physiology29 Feb 2024

More on DNA damage response

Collagen 1

downin human cells1

1 study

  1. Hsa-mirvana MIR-146A inhibitor decreases collagen 1 in human cells.

    “downregulation of miR-146a results in a reduction of cellular proliferation, Collagen-1 production”

    Cellsin NHDFsskin

    miR-146a is a critical target associated with multiple biological pathways of skin aging

    Frontiers in physiology29 Feb 2024

More on Collagen 1

Cell proliferation

downin human cells1

1 study

  1. Hsa-mirvana MIR-146A inhibitor decreases cell proliferation in human cells.

    “downregulation of miR-146a results in a reduction of cellular proliferation, Collagen-1 production, as well as an increase in DNA damage and pro-inflammatory markers”

    Cellsin NHDFsskin

    miR-146a is a critical target associated with multiple biological pathways of skin aging

    Frontiers in physiology29 Feb 2024