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Histatin 1

Intervention

1 paper studies it3 findings

PubChem

Across all fields, 1 paper: none in people yet, 1 in animals

More peptides

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals1

Outcomes

3

Wound healing

upin mice1

1 study

  1. Histatin 1 improves wound healing in mice.

    “In an in vivo mouse model of diabetes mellitus skin defects, Hst1 facilitated wound healing by stimulating the new blood vessel formation and impeding the expression of senescent biomarkers.”

    Animalsin diabetic mice

    Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair

    Free radical biology & medicine

Oxidative stress and ROS signaling

downin human cells1

1 study

  1. Histatin 1 decreases oxidative stress and ROS signaling in human cells.

    “Hst1 induces ERK-mediated Nrf2 nuclear translocation through NADPH oxidase-dependent ROS regulation, reinforced Nrf2 antioxidant response, and suppressed oxidative stress.”

    Cellsin HUVECs

    Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair

    Free radical biology & medicine

More on Oxidative stress and ROS signaling

Cellular senescence

downin human cells1

1 study

  1. Histatin 1 decreases cellular senescence in human cells.

    “Hst1 decreased staining for senescence-associated β-galactosidase activity and expression of mediators of senescence signaling, including p53, p21, and p16.”

    Cellsin aging HUVECs

    Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair

    Free radical biology & medicine

More on Cellular senescence

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