High-protein high-unsaturated-fat diet

1. High-protein high-unsaturated-fat diet has no effect on insulin resistance in humans (P = 0.799 for triglycerides, P = 0.124 for insulin resistance).

   “Both groups decreased in triglycerides and insulin resistance (P for difference between groups P = 0.799 and P = 0.124, respectively).”

   Human trial12 mo

   Effect of unsaturated fat and protein intake on liver fat in people at risk of unhealthy aging: 1-year results of a randomized controlled trial

   The American journal of clinical nutrition·Jan 13, 2023

1. High-protein high-unsaturated-fat diet decreases LDL cholesterol in humans (P = 0.019 for LDL-C, P = 0.010 for TC).

   “Compared with the CG, decline of LDL cholesterol (LDL-C) and total cholesterol (TC) was stronger in the IG (for LDL-C P = 0.019, for TC P = 0.010).”

   Human trial12 mo

   Effect of unsaturated fat and protein intake on liver fat in people at risk of unhealthy aging: 1-year results of a randomized controlled trial

   The American journal of clinical nutrition·Jan 13, 2023

More on LDL cholesterol

1. High-protein high-unsaturated-fat diet decreases intrahepatic lipid content in humans (-42.1% (95% CI: -58.1, -20.1%) vs -22.2% (95% CI: -40.7, 2.0%), P = 0.013).

   “an effect that became significant by comparing adherent IG subjects to adherent CG subjects (-42.1%; 95% CI: -58.1, -20.1%; n = 88 compared with -22.2%; 95% CI: -40.7, 2.0%; n = 121; P = 0.013).”

   Human trialadherent subjects, adjusted for weight loss, sex, and ageliver12 mo

   Effect of unsaturated fat and protein intake on liver fat in people at risk of unhealthy aging: 1-year results of a randomized controlled trial

   The American journal of clinical nutrition·Jan 13, 2023

More on Intrahepatic lipid content