Hepatocyte transplantation

1. Hepatocyte transplantation increases liver repopulation in rats (91+/-7%).

   “Extensive (91+/-7%) liver replacement by transplanted hepatocytes was observed in animals sacrificed 18 months posttransplantation.”

   Animalsin retrorsine-treated ratsliver18 months

   Liver repopulation by transplanted hepatocytes and risk of hepatocellular carcinoma

   Transplantation·27 Nov 2006

1. Hepatocyte transplantation increases transplanted hepatocyte cluster size in rats.

   “Subsequently, transplanted cells proliferated again, with increased sizes of transplanted cell clusters at 18 and 24 mo of age.”

   Animalsliver

   Transplanted reporter cells help in defining onset of hepatocyte proliferation during the life of F344 rats

   American journal of physiology. Gastrointestinal and liver physiology·1 Sep 2000

1. Hepatocyte transplantation decreases hepatocyte number in rats.

   “The hepatocyte number significantly decreased within the first week following implantation.”

   Animalswithin the first week following implantationliver

   Long-term differentiated function of heterotopically transplanted hepatocytes on three-dimensional polymer matrices

   Journal of biomedical materials research·15 Dec 1999

More on Hepatocyte number