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Hemodynamic stress

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Heart and Stroke Foundation of Canada and 4 more
  • 2 of 2 findings with company ties
  • Humans1

Outcomes

2

Telomere length

downin humans1

1 study

  1. Hemodynamic stress decreases telomere length in humans (147 bp/yr vs. 87 bp/yr, P < 0.05).

    “the rate of telomere loss as a function of donor age was greater in the intimal DNA of iliac arteries compared to that of the internal thoracic arteries (147 bp/yr vs. 87 bp/yr, respectively, P < 0.05)”

    Humansintima

    Telomere length and replicative aging in human vascular tissues

    Proceedings of the National Academy of Sciences of the United States of America21 Nov 1995

More on Telomere length

Mean TRF length

downin humans1

1 study

  1. Hemodynamic stress decreases mean TRF length in humans (102 bp/yr vs. 47 bp/yr, P < 0.05).

    “there was a significantly greater rate of decrease for cells from iliac arteries than from iliac veins (102 bp/yr vs. 47 bp/yr, respectively, P < 0.05)”

    Humansiliac artery

    Telomere length and replicative aging in human vascular tissues

    Proceedings of the National Academy of Sciences of the United States of America21 Nov 1995

More on Mean TRF length

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