Healthy sleep pattern

2 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Humans2

Outcomes

White matter hyperintensity

downin humans1

1 study

Healthy sleep pattern decreases white matter hyperintensity in humans (p < 0.05).
“along with lower white matter hyperintensity (all p < 0.05).”
Humans
Associations of Adherence to a Healthy Sleep Pattern with the Dementia Risk in the UK Biobank
AAIC 2025 abstract23 Dec 2025

Total brain volume

upin humans1

1 study

Healthy sleep pattern increases total brain volume in humans (p < 0.05).
“Sticking to a healthy sleep pattern was associated with increased total brain, white matter, and grey matter volumes, along with lower white matter hyperintensity (all p < 0.05).”
Humans
Associations of Adherence to a Healthy Sleep Pattern with the Dementia Risk in the UK Biobank
AAIC 2025 abstract23 Dec 2025

Fasting glucose

downin humans1

1 study

Healthy sleep pattern decreases fasting glucose in humans (β: -4.69, SE: 0.97).
“The HSP was significantly inversely associated with the glucose (β: -4.69, SE: 0.97; p<0.001), HbA1c (β: -0.12, SE: 0.04; p<0.001)”
Humansn = 1,184
MON-574 Healthy sleep patterns, plasma metabolome, and type 2 diabetes: the Bogalusa Heart Study
ENDO 2025 abstract22 Oct 2025

Associations

Dementia

downin humans1HR 0.93

1 study

Healthy sleep pattern lowers the risk of dementia in humans (HR 0.93 (95% CI: 0.89–0.96) per 1-point increase).
“with each 1‐point increase in the score, the hazard ratio (HR) (0.93; 95% confidence interval [CI]: 0.89–0.96) decreased by 7.0%.”
Humans
Associations of Adherence to a Healthy Sleep Pattern with the Dementia Risk in the UK Biobank
AAIC 2025 abstract23 Dec 2025