GSK126

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 2 more
  • Animals1

Outcomes

2

Cellular senescence

downin mice1−54%

1 study
  1. GSK126 decreases cellular senescence in mice (~54%).

    “Pharmacological inhibition of EZH2 by GSK126 alleviated kidney aging and podocyte injury markers by approximately 54% in db/db mice.”

    Animalsin db/db mice

    Histone methyltransferase EZH2 drives podocyte injury and senescence in diabetic nephropathy through STAT3 activation

    Cellular and molecular life sciences : CMLS11 Mar 2026

More on Cellular senescence

Podocyte injury

downin mice1−54%

1 study
  1. GSK126 decreases podocyte injury in mice (~54%).

    “Pharmacological inhibition of EZH2 by GSK126 alleviated kidney aging and podocyte injury markers by approximately 54% in db/db mice.”

    Animalsin db/db mice

    Histone methyltransferase EZH2 drives podocyte injury and senescence in diabetic nephropathy through STAT3 activation

    Cellular and molecular life sciences : CMLS11 Mar 2026

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