Grifola frondosa

1. Grifola frondosa increases natural killer cells in humans.

   “The activity of natural killer cells, a type of immune cell, was also significantly augmented in the Y10M group”

   Human trialbread containing 50 g of the maitake mushroom strain Y10M18 wkn = 47

   Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial

   Journal of nutritional science and vitaminology·1 Jan 2026

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1. Grifola frondosa has no effect on MoCA-J in humans.

   “However, no difference was observed in the MoCA-J scores between the C5304 and placebo groups.”

   Human trialbread containing 50 g of the maitake mushroom strain C530418 wkn = 47

   Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial

   Journal of nutritional science and vitaminology·1 Jan 2026

More on MoCA-J

1. Grifola frondosa improves cognitive function in humans.

   “The Y10M group showed a significant improvement in cognitive assessment based on the Japanese version of the Montreal Cognitive Assessment (MoCA-J) score compared to the placebo group after the intervention.”

   Human trialbread containing 50 g of the maitake mushroom strain Y10M18 wkn = 47

   Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial

   Journal of nutritional science and vitaminology·1 Jan 2026

1. Grifola frondosa decreases TNF-alpha in rats.

   “TNFa levels decreased in all four test groups suggesting a lessening of the inflammatory state.”

   Animalsin mature female SD rats on high-sucrose dietfour monthsfemales

   Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats

   International journal of medical sciences·7 Jun 2010

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1. Grifola frondosa improves insulin sensitivity in rats.

   “and were more sensitive to exogenous insulin challenge.”

   Animalsin mature female SD rats on high-sucrose dietfour monthsfemales

   Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats

   International journal of medical sciences·7 Jun 2010

1. Grifola frondosa inhibits renin–angiotensin system in rats.

   “treatment groups showed decreased activity of the RAS estimated by less lowering of SBP after losartan challenge and decreased serum ACE activity”

   Animalsin mature female SD rats on high-sucrose dietfour monthsfemales

   Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats

   International journal of medical sciences·7 Jun 2010

More on Renin–angiotensin system

1. Grifola frondosa decreases systolic blood pressure in rats.

   “implementation of all test conditions stopped the gradual elevation of systolic blood pressure (SBP) in the SD over the four months of study, even reversing some of the previous elevation”

   Animalsin mature female SD rats on high-sucrose dietfour monthsfemales

   Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats

   International journal of medical sciences·7 Jun 2010