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GLX351322

Intervention

1 paper studies it2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

2

Intraocular pressure

downin mice1

1 study

  1. GLX351322 decreases intraocular pressure in mice.

    “cotreatment with GLX351322 alleviating elevations in IOP.”

    Animalsin DEX-ac-treated mice

    Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis

    Cell transplantationJan 1, 2023

More on Intraocular pressure

Cellular senescence

downin human cells1

1 study

  1. GLX351322 prevents cellular senescence in human cells.

    “inhibiting NOX4 with GLX351322 and scavenging ROS with NAC were both effective in preventing DEX-induced senescence changes.”

    Cellsin DEX-treated HTMCs

    Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis

    Cell transplantationJan 1, 2023

More on Cellular senescence

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