FPS-ZM1
- 2 independent labs in 1 country
- Funders: National Natural Science Foundation of China and 1 more
Outcomes
2ER unfolded protein response
downin human cells1
1 study
ER unfolded protein response
downin human cells1
FPS-ZM1 inhibits ER unfolded protein response in human cells.
“pharmacological RAGE blockade using FPS-ZM1 successfully reversed these pathological alterations, attenuating ER stress responses, oxidative dysregulation, and functional deterioration triggered by the combined treatment regimen.”
Cellsin SHEDs treated with high glucose and AGEs
Histochemistry and cell biology
Inflammation
downin human cells1
1 study
Inflammation
downin human cells1
FPS-ZM1 decreases inflammation in human cells.
“Antagonizing RAGE effectively blocked AGE-induced inflammaging, glycolysis, and AKT/mTOR pathway activation.”
Cellsin AGE-treated hPDLFsperiodontal ligament
Acta odontologica Scandinavica
Latest
3 papers in 12 monthsJournal of Inflammation Research
Hydroxygenkwanin Identified in Rehmanniae Radix Praeparata-Corni Fructus Ameliorates Postmenopausal Osteoporosis via Modulation of the AGE-RAGE Signaling Pathway
Experiments in ratsPostmenopausal osteoporosis
Histochemistry and Cell Biology
AGEs derived from high-sugar diets induce functional impairment of odontogenic stem cells via RAGE-mediated endoplasmic reticulum stress
Experiments in human cellsER unfolded protein response
Experimental & Molecular Medicine
Deconstructing the RAGE signaling maze: the molecular key to opening a new dimension of ovarian anti-aging
ReviewAGE–RAGE signaling
Acta Odontologica Scandinavica
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway
Experiments in human cellsmTOR signaling