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FOXO4-DRI

InterventionSenolytics

1 paper3 findings

PubChem 167312269

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 2 countries
  • Funders: Austrian Science Fund and 6 more
  • Animals1

Outcomes

3

Renal function

upin mice1

1 study

  1. FOXO4-DRI improves renal function in mice.

    “Moreover, it restored fitness, fur density, and renal function in both fast aging XpdTTD/TTD and naturally aged mice.”

    Animalsin XpdTTD/TTD and naturally aged micekidney

    Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

    Cell23 Mar 2017

Fitness

upin mice1

1 study

  1. FOXO4-DRI improves fitness in mice.

    “Moreover, it restored fitness, fur density, and renal function in both fast aging XpdTTD/TTD and naturally aged mice.”

    Animalsin XpdTTD/TTD and naturally aged mice

    Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

    Cell23 Mar 2017

Chemotoxicity

downin mice1

1 study

  1. FOXO4-DRI protects against chemotoxicity in mice.

    “this FOXO4 peptide neutralized doxorubicin-induced chemotoxicity.”

    Animalsin doxorubicin-treated mice

    Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

    Cell23 Mar 2017

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