FOXO3 overexpression

Intervention1 paper4 findings

Outcomes

Cell proliferation

downin chicken cells1

1 study

FOXO3 overexpression decreases cell proliferation in chicken cells.
Cellsprimordial germ cell
FOXO3 overexpression delays primordial follicle activation in chickens · Poultry science · 21 Sep 2026

Apoptosis

downin chickens1

1 study

FOXO3 overexpression decreases apoptosis in chickens.
Animalsat 3 dphovaryfemales
FOXO3 overexpression delays primordial follicle activation in chickens · Poultry science · 21 Sep 2026

PI3K–AKT signalling

downin chickens1

1 study

FOXO3 overexpression inhibits PI3K–AKT signalling in chickens.
Animalsat 4 dphovaryfemales
FOXO3 overexpression delays primordial follicle activation in chickens · Poultry science · 21 Sep 2026

Primordial follicle activation

downin chickens1

1 study

FOXO3 overexpression decreases primordial follicle activation in chickens.
Animalsin germline chimeric chickensovary21 daysfemales
FOXO3 overexpression delays primordial follicle activation in chickens · Poultry science · 21 Sep 2026

AnimalsPeer-reviewed1 Oct

Overexpressing the transcription factor kept avian follicles dormant and suppressed PI3K and AKT signaling during early ovarian development.

Poultry science · Lan M et al.