Flock house virus

Flock house virus has been studied in 2 papers since 2021: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Mar 22, 2023: “RNA virus-mediated changes in organismal oxygen consumption rate in young and old Drosophila melanogaster males”.

Intervention

2 papers study it3 findingsUpdated

See all 2

None of its findings points the other way.

  • 1 lab in 1 country
  • Funders: University of Alabama and 5 more
  • Model organisms2

What did studies of Flock house virus find?

3

Studies of Flock house virus measured 3 outcomes; the most studied are lifespan (1 study), differential gene regulation (1) and mortality (1).

Lifespan

downin flies1

1 study
  1. Flock house virus shortens lifespan in flies (Flock House virus infection).

    “older flies die faster than younger flies due to impaired disease tolerance”

    Model organismsFlock House virus infectionmales

    RNA virus-mediated changes in organismal oxygen consumption rate in young and old Drosophila melanogaster males

    Aging

Differential gene regulation

upin flies1

1 study
  1. Flock house virus increases differential gene regulation in older flies compared with younger flies.

    “older Drosophila mount transcriptional responses characterized by differential regulation of more genes and genes regulated to a greater extent”

    Model organismsin older flies compared with younger flies

    Age-dependent impairment of disease tolerance is associated with a robust transcriptional response following RNA virus infection in Drosophila

    G3 (Bethesda, Md.)

More on Differential gene regulation

Mortality

upin flies1

1 study
  1. Flock house virus increases mortality in aged flies compared with younger flies.

    “aged Drosophila succumb more rapidly to infection with the RNA-containing Flock House virus due to an age-dependent defect in disease tolerance”

    Model organismsin aged flies compared with younger flies

    Age-dependent impairment of disease tolerance is associated with a robust transcriptional response following RNA virus infection in Drosophila

    G3 (Bethesda, Md.)

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