Famine exposure

1. Famine exposure impairs self-rated health in humans (IRR 1.06, 95% CI 1.04–1.07, p < .001).

   “The first generation (F1) exposed to famine in utero, infancy, pre-school, primary school, or adolescence had poorer self-rated health than those unexposed (IRR=1.06, 95% CI [1.04 – 1.07], p <.001).”

   Humans

   LONG-TERM AND INTERGENERATIONAL EFFECTS OF EARLY-LIFE EXPOSURE TO THE 1959–1961 CHINESE FAMINE ON HEALTH

   GSA 2024 abstract·31 Dec 2024

1. Famine exposure raises the risk of chronic kidney disease in humans (OR 2.09, 95% CI 1.16-3.76).

   “Severe famine exposure combined with frequent meat consumption was associated with higher odds of prevalent CKD (odds ratio, 2.09; 95% confidence interval, 1.16-3.76).”

   Humanscombined with frequent meat consumption in CNHSn = 7,238

   Life-course metabolic vulnerability and chronic kidney disease risk after early-life famine exposure in middle-aged and older Chinese adults

   The journals of gerontology. Series A, Biological sciences and medical sciences·7 Jul 2026

2. Famine exposure is associated with chronic kidney disease in humans (OR 1.04, 95% CI 1.01-1.07 per unit increase in shrinkage index).

   “the famine-CKD association increased with regional famine intensity, with an interaction odds ratio of 1.04 per unit increase in cohort size shrinkage index (95% confidence interval, 1.01-1.07).”

   Humansregional famine intensity in CNHSn = 7,238

   Life-course metabolic vulnerability and chronic kidney disease risk after early-life famine exposure in middle-aged and older Chinese adults

   The journals of gerontology. Series A, Biological sciences and medical sciences·7 Jul 2026

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