Familial loss of a loved one

1. Familial loss of a loved one has no effect on Horvath clock in humans (β = -0.08; 95% CI, -0.23 to 0.06).

   “there were no associations with 2 or more losses for the Horvath clock (β = -0.08; 95% CI, -0.23 to 0.06).”

   Humans2 or more familial losses compared with no losses; no association detectedblood24 yearsn = 3,963

   Familial Loss of a Loved One and Biological Aging: NIMHD Social Epigenomics Program

   JAMA network open·1 Jul 2024

More on Horvath clock

1. Familial loss of a loved one is associated with DunedinPACE in humans (β = 0.22; 95% CI, 0.10 to 0.34).

   “DunedinPACE β = 0.22; 95% CI, 0.10 to 0.34) compared with those with no losses.”

   Humans2 or more familial losses compared with no lossesblood24 yearsn = 3,963

   Familial Loss of a Loved One and Biological Aging: NIMHD Social Epigenomics Program

   JAMA network open·1 Jul 2024

More on DunedinPACE

1. Familial loss of a loved one is associated with GrimAge in humans (β = 0.27; 95% CI, 0.09 to 0.45).

   “GrimAge β = 0.27; 95% CI, 0.09 to 0.45;”

   Humans2 or more familial losses compared with no lossesblood24 yearsn = 3,963

   Familial Loss of a Loved One and Biological Aging: NIMHD Social Epigenomics Program

   JAMA network open·1 Jul 2024

More on GrimAge

1. Familial loss of a loved one is associated with PhenoAge in humans (β = 0.15; 95% CI, 0.02 to 0.28).

   “Those who experienced 2 or more losses tended to have older biological ages for several of the clocks (PhenoAge β = 0.15; 95% CI, 0.02 to 0.28;”

   Humans2 or more familial losses compared with no lossesblood24 yearsn = 3,963

   Familial Loss of a Loved One and Biological Aging: NIMHD Social Epigenomics Program

   JAMA network open·1 Jul 2024

More on PhenoAge