Familial longevity
Familial longevity has been studied in 3 papers since 2017: 3 observational studies in people. The newest paper, Jan 14, 2023: “Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study”.
3 papers study it6 findingsUpdated
See all 3 papers on familial longevity
At a glance
The findings reach people, from one lab or study. 2 independent labs in 2 countries.
“offspring were 46% less likely to have baseline cognitive impairment (adjusted odds ratio 0.54, 95% CI 0.35-0.82)”
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Instituto de Salud Carlos III and 3 more
- Humans3
What did studies of familial longevity find?
4Studies of familial longevity measured 4 outcomes, among them muscle mass, IL-6 and robust status.
Muscle mass
no changein humans1
1 study
Muscle mass
no changein humans1
Familial longevity was not clearly linked with muscle mass in humans.
“No significant differences in muscle mass were found.”
Humans
Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study
International journal of environmental research and public health
IL-6
downin humans1
1 study
IL-6
downin humans1
Familial longevity is linked with lower IL-6 in humans.
“and lower levels of IL-6 (p = 0.044) than controls.”
Humans
Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study
International journal of environmental research and public health
Robust status
upin humans1OR 3
1 study
Robust status
upin humans1OR 3
Familial longevity is linked with higher robust status in humans (adjusted OR 3.00 (95% CI 1.06-8.47)).
“The robust adjusted OR for cases was 3.00 (95% CI = 1.06-8.47, p = 0.038).”
Humans
Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study
International journal of environmental research and public health
Frailty
downin humans1
1 study
Frailty
downin humans1
Familial longevity is linked with lower frailty in humans (frail 9.1% vs. 21.6% in controls).
“Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%)”
Humans
Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study
International journal of environmental research and public health
What is familial longevity linked with?
2Studies link familial longevity with 2 measures: incident cognitive impairment and cognitive impairment.
Incident cognitive impairment
downin humans1
1 study
Incident cognitive impairment
downin humans1
Familial longevity is linked with a lower risk of incident cognitive impairment in humans (adjusted for age, sex, education, stroke, and diabetes) (adjusted hazard ratio 0.73, 95% CI 0.53-0.99).
“were 27% less likely to become cognitively impaired over a median follow-up of 7.8 years (adjusted hazard ratio 0.73, 95% CI 0.53-0.99)”
Humansadjusted for age, sex, education, stroke, and diabetesmedian follow-up of 7.8 years
Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring
The journals of gerontology. Series A, Biological sciences and medical sciences
Cognitive impairment
downin humans1
1 study
Cognitive impairment
downin humans1
Familial longevity is linked with a lower risk of cognitive impairment in humans (adjusted for age, sex, education, stroke, and diabetes) (adjusted odds ratio 0.54, 95% CI 0.35-0.82).
“offspring were 46% less likely to have baseline cognitive impairment (adjusted odds ratio 0.54, 95% CI 0.35-0.82)”
Humansadjusted for age, sex, education, stroke, and diabetes
Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring
The journals of gerontology. Series A, Biological sciences and medical sciences