L-citrulline + leucine + exercise

L-citrulline + leucine + exercise improves physical function in humans.

“yields superior enhancements in muscle mass, vascular reactivity, and physical performance compared to isolated interventions alone.”

Reviewcombined supplementation and structured exercise compared with isolated interventions

Targeting muscle-vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention

Frontiers in nutrition·Apr 2, 2026

L-citrulline + leucine + exercise improves vascular reactivity in humans.

“yields superior enhancements in muscle mass, vascular reactivity, and physical performance compared to isolated interventions alone.”

Reviewcombined supplementation and structured exercise compared with isolated interventionsvasculature

Targeting muscle-vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention

Frontiers in nutrition·Apr 2, 2026

L-citrulline + leucine + exercise increases muscle mass in humans.

“yields superior enhancements in muscle mass, vascular reactivity, and physical performance compared to isolated interventions alone.”

Reviewcombined supplementation and structured exercise compared with isolated interventionsskeletal muscle

Targeting muscle-vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention

Frontiers in nutrition·Apr 2, 2026