Ethosuximide
Ethosuximide has been studied in 3 papers since 2017: none in people yet, 3 in animals. The research so far is in animals. The newest paper, Feb 28, 2024: “Thermosensitive hydrogel containing ethosuximide-loaded multivesicular liposomes attenuates age-related hearing loss in C57BL/6J mice”.
See all 4 papers on ethosuximide
At a glance
The findings reach mice, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: National Natural Science Foundation of China and 2 more
- Animals2
- Model organisms1
What did studies of ethosuximide find?
4Studies of ethosuximide measured 4 outcomes; the most studied are auditory brainstem response threshold shift (1 study), spiral ganglion neuron loss (1) and auditory function (1).
Auditory brainstem response threshold shift
downin mice1
1 study
Auditory brainstem response threshold shift
downin mice1
Ethosuximide decreases auditory brainstem response threshold shift in mice (compared to oral systemic administration) (p < 0.05).
“the intratympanic ethosuximide-loaded MVLs-Gel injection group showed significantly lower auditory brainstem response threshold shifts at stimulus frequencies of 4, 8, and 16 kHz”
Animalscompared to oral systemic administrationthermosensitive hydrogel containing ethosuximide-encapsulated multivesicular liposomes8 weeks
Neuroscience letters
Spiral ganglion neuron loss
downin mice1
1 study
Spiral ganglion neuron loss
downin mice1
Ethosuximide decreases spiral ganglion neuron loss in mice (compared to oral systemic administration) (p < 0.05).
“intratympanic ethosuximide-loaded MVLs-Gel injection dramatically reduced the loss of age-related spiral ganglion neurons in the apical turns of the mice”
Animalscompared to oral systemic administrationthermosensitive hydrogel containing ethosuximide-encapsulated multivesicular liposomes8 weeks
Neuroscience letters
Auditory function
upin mice1
1 study
Auditory function
upin mice1
Ethosuximide improves auditory function in mice.
“auditory function was significantly improved in the ethosuximide-treated group compared to the untreated group”
Animalsintraperitoneal injectionP7 until 8 weeks of age
Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss
International journal of molecular medicine
Hair cell and spiral ganglion neuron loss
downin mice1
1 study
Hair cell and spiral ganglion neuron loss
downin mice1
Ethosuximide decreases hair cell and spiral ganglion neuron loss in mice.
“Hair cell and SGN was were significantly lower”
Animalsintraperitoneal injectioncochleaP7 until 8 weeks of age
Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss
International journal of molecular medicine