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ERP18 knockdown

InterventionPreclinical

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Japan Agency for Medical Research and Development and 3 more
  • Model organisms1

Outcomes

1

Lifespan

downin worms1

1 study

  1. ERP18 knockdown shortens lifespan in worms.

    “ERp18 knockdown in C. elegans without Prx4 and GPx7/8, both of which are also known to have H2O2 scavenging activity in the ER, shortened the lifespan”

    Model organismsin C. elegans without Prx4 and GPx7/8

    Zn²⁺-dependent functional switching of ERp18, an ER-resident thioredoxin-like protein

    Cell reports7 Feb 2024

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