Embryonic stem cell-derived small extracellular vesicles

1. Embryonic stem cell-derived small extracellular vesicles decrease cellular senescence in human cells.

   “we confirmed ESC-sEVs reversed senescent phenotype in ex-vivo cultured human end-stage OA cartilage explants.”

   Cellsex-vivo cultured human end-stage OA cartilage explantscartilage

   ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis

   Pharmacological research·Oct 19, 2024

2. Embryonic stem cell-derived small extracellular vesicles decrease cellular senescence in mice.

   “ESC-sEVs ameliorated senescent phenotype and cartilage destruction in both mechanical stress-induced non-early-stage posttraumatic OA and naturally aged mice.”

   Animalsin mechanical stress-induced non-early-stage posttraumatic OA and naturally aged mice

   ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis

   Pharmacological research·Oct 19, 2024

More on Cellular senescence

1. Embryonic stem cell-derived small extracellular vesicles decrease cartilage destruction in mice.

   “ESC-sEVs ameliorated senescent phenotype and cartilage destruction in both mechanical stress-induced non-early-stage posttraumatic OA and naturally aged mice.”

   Animalsin mechanical stress-induced non-early-stage posttraumatic OA and naturally aged mice

   ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis

   Pharmacological research·Oct 19, 2024