Elimination of p16ink4a+ senescent endothelial cells

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: American Heart Association and 6 more

Animals1

Outcomes

Metabolic dysfunction

downin mice1

1 study

Elimination of p16ink4a+ senescent endothelial cells decrease metabolic dysfunction in mice.
“Targeted removal of senescent endothelial cells from obese Tie2-Cre;p16Ink4a-LOX-ATTAC mice attenuated the pro-inflammatory senescence-associated secretory phenotype and alleviated metabolic dysfunction.”
Animalsin obese Tie2-Cre;p16Ink4a-LOX-ATTAC mice
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
Cell metabolism20 Nov 2025

Latest

1 in 12 months

Cell Metabolism22 Nov

Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice

Experiments in miceMetabolic dysfunction

Paper

Elimination of p16ink4a+ senescent endothelial cells

Outcomes

Latest

Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice

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