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Early age at menarche

Exposure

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Humans1

Associations

3

Myocardial infarction

upin humans1OR 2.59

1 study

  1. Early age at menarche raises the risk of myocardial infarction in humans (OR 2.59).

    “MI (OR 2.33/2.59), and heart failure (OR 2.50/2.60) (all p<0.05).”

    Humansfemalesn = 7,623

    OR15-08 Early and Late Age at Menarche and their Distinct Cardiometabolic and Reproductive Outcomes: The Brazilian Longitudinal Study of Adult Health

    ENDO 2025 abstract22 Oct 2025

More on Myocardial infarction

Type 2 diabetes

upin humans1OR 1.92

1 study

  1. Early age at menarche raises the risk of type 2 diabetes in humans (OR 1.92).

    “T2DM (OR 1.85/1.92), metabolic syndrome (OR 1.58/1.57), elevated uric acid (OR 1.47/1.48), pre-eclampsia (OR 1.71/1.67), self-reported angina (OR 1.76/1.68), MI (OR 2.33/2.59), and heart failure (OR 2.50/2.60) (all p<0.05).”

    Humansfemalesn = 7,623

    OR15-08 Early and Late Age at Menarche and their Distinct Cardiometabolic and Reproductive Outcomes: The Brazilian Longitudinal Study of Adult Health

    ENDO 2025 abstract22 Oct 2025

More on Type 2 diabetes

Obesity

upin humans1OR 2.08

1 study

  1. Early age at menarche raises the risk of obesity in humans (OR 2.08).

    “Early AAM was associated with higher odds of multiple adverse outcomes in both univariable and multivariable analyses: obesity (OR 2.18/2.08)”

    Humansfemalesn = 7,623

    OR15-08 Early and Late Age at Menarche and their Distinct Cardiometabolic and Reproductive Outcomes: The Brazilian Longitudinal Study of Adult Health

    ENDO 2025 abstract22 Oct 2025

More on Obesity

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