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Dpn

Intervention

2 papers4 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Natural Sciences and Engineering Research Council of Canada and 1 more
  • Animals2

Outcomes

4

Follicle activation

downin rats1

1 study

  1. Dpn decreases follicle activation in rats.

    “a selective agonist (DPN) decreased follicle activation”

    Animalsovary

    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

    EndocrinologyApr 1, 2020

Anxiety-like behavior

downin mice1

1 study

  1. Dpn decreases anxiety-like behavior in mice.

    “DPN administration had anxiolytic-like effects when measured using an elevated plus maze at 9 months of age.”

    Animalsin ovariectomized female micedietary feed3 mg/kg/dayfemales

    Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice

    GeroScienceAug 11, 2018

Running speed

upin mice1

1 study

  1. Dpn increases running speed in mice.

    “were as likely as control mice to engage in extended bouts of wheel running, and did so at higher average speeds.”

    Animalsin ovariectomized female micedietary feed3 mg/kg/dayfemales

    Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice

    GeroScienceAug 11, 2018

Body mass

upin mice1

1 study

  1. Dpn increases body mass in mice.

    “DPN-treated mice gained more body mass over the first 2 years of age (17 months of the study).”

    Animalsin ovariectomized female micedietary feed3 mg/kg/day17 monthsfemales

    Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice

    GeroScienceAug 11, 2018

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