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Doxorubicin + INTERLEUKIN-2

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Cancer Institute
  • Animals1

Outcomes

2

Immune response

upin mice1

1 study

  1. Doxorubicin + INTERLEUKIN-2 induces immune response in mice.

    “Functionally they developed high levels of anti-EL4 activity, which was ablated by combined treatment with monoclonal antibodies against CD8 and CD44, indicating the role of memory cells.”

    Animalscured of EL4 lymphoma with doxorubicin and interleukin-2

    Specific anti-EL4-lymphoma immunity in mice cured 2 years earlier with doxorubicin and interleukin-2

    Cancer immunology, immunotherapy : CII1 May 1996

More on Immune response

Survival

upin mice1

1 study

  1. Doxorubicin + INTERLEUKIN-2 improves survival in mice (all of them survived).

    “At about 2 years of age EL4 was reimplanted into mice; all of them survived.”

    Animalscured 2 years earlier with doxorubicin and interleukin-2

    Specific anti-EL4-lymphoma immunity in mice cured 2 years earlier with doxorubicin and interleukin-2

    Cancer immunology, immunotherapy : CII1 May 1996

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