Diphtheria toxin

1. Diphtheria toxin decreases senescence-associated secretory phenotype (SASP) in mice.

   “Moreover, CD11b+ cell ablation led to a marked decrease in SASPs markers (p16 and Il-16) at both transcriptional and protein levels in vWAT and the liver.”

   Animalsin intermittent hypoxia-exposed micevisceral white adipose tissue and liver6 weeks

   Systemic depletion of CD11b+ cells improves metabolic function in murine model of sleep apnea induced by intermittent hypoxia

   Sleep·27 Apr 2026

More on Senescence-associated secretory phenotype (SASP)

1. Diphtheria toxin decreases macrophage infiltration in mice.

   “Macrophage infiltration, assessed by F4/80 or CD11b immunostaining, was significantly reduced following CD11b ablation in IH-exposed mice compared with controls in both males and females.”

   Animalsin intermittent hypoxia-exposed mice6 weeks

   Systemic depletion of CD11b+ cells improves metabolic function in murine model of sleep apnea induced by intermittent hypoxia

   Sleep·27 Apr 2026

1. Diphtheria toxin improves insulin sensitivity in mice.

   “Depletion of CD11b+ cells in mice exposed to IH resulted in significant improvements in metabolic function and insulin sensitivity.”

   Animalsin intermittent hypoxia-exposed mice6 weeks

   Systemic depletion of CD11b+ cells improves metabolic function in murine model of sleep apnea induced by intermittent hypoxia

   Sleep·27 Apr 2026