Dietary reversal

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute of General Medical Sciences and 4 more

Animals1

Outcomes

Insulin tone

upin mice1

1 study

Dietary reversal improves insulin tone in mice.
“improved hippocampal and midbrain insulin tone”
Animalsprior high-fat dietbrain2 monthsmalesn = 9
Reversal of early-life high fat diet prevents spatial discrimination deficits corresponding with altered brain inflammatory and metabolic profiles in male C57BL/6J mice
Nutritional neuroscience25 Nov 2025

GFAP

downin mice1

1 study

Dietary reversal decreases GFAP in mice.
“lower hippocampal GFAP, increased hippocampal MCP1 and IL4, improved hippocampal and midbrain insulin tone”
Animalsprior high-fat diethippocampus2 monthsmalesn = 9
Reversal of early-life high fat diet prevents spatial discrimination deficits corresponding with altered brain inflammatory and metabolic profiles in male C57BL/6J mice
Nutritional neuroscience25 Nov 2025

Latest

1 in 12 months

Nutritional Neuroscience25 Nov

Reversal of early-life high fat diet prevents spatial discrimination deficits corresponding with altered brain inflammatory and metabolic profiles in male C57BL/6J mice

Experiments in miceInterventions

Paper

Dietary reversal

Outcomes

Latest

Reversal of early-life high fat diet prevents spatial discrimination deficits corresponding with altered brain inflammatory and metabolic profiles in male C57BL/6J mice

Related