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Dietary methionine restriction

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Animals1

Outcomes

4

Albumin-to-creatinine ratio

downin mice1

1 study

  1. Dietary methionine restriction decreases albumin-to-creatinine ratio in mice.

    “Urine albumin, creatinine, albumin-to-creatinine ratio, sulfur amino acids, and electrolytes were reduced in MR mice.”

    Animalsin unilateral nephrectomized and 5/6 nephrectomized mice

    Dietary methionine restriction modulates renal response and attenuates kidney injury in mice

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology4 Jan 2018

More on Albumin-to-creatinine ratio

Extracellular matrix remodelling

downin mice1

1 study

  1. Dietary methionine restriction inhibits extracellular matrix remodelling in mice.

    “MR attenuated kidney injury in 5/6Nx mice by down-regulating inflammation and fibrosis mechanisms.”

    Animalsin micekidney

    Dietary methionine restriction modulates renal response and attenuates kidney injury in mice

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology4 Jan 2018

More on Extracellular matrix remodelling

Inflammation

downin mice1

1 study

  1. Dietary methionine restriction inhibits inflammation in mice.

    “MR attenuated kidney injury in 5/6Nx mice by down-regulating inflammation and fibrosis mechanisms.”

    Animalsin micekidney

    Dietary methionine restriction modulates renal response and attenuates kidney injury in mice

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology4 Jan 2018

More on Inflammation

Kidney injury

downin mice1

1 study

  1. Dietary methionine restriction protects against kidney injury in mice.

    “MR attenuated kidney injury in 5/6Nx mice by down-regulating inflammation and fibrosis mechanisms.”

    Animalsin 5/6 nephrectomized micekidney

    Dietary methionine restriction modulates renal response and attenuates kidney injury in mice

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology4 Jan 2018

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