Diet-induced obesity

1. Diet-induced obesity activates AGE–RAGE signalling in mice.

   “scRNA-seq of gastrocnemius FAPs demonstrated increased advanced glycation end-product (AGE) signaling”

   Animalsgastrocnemius

   MON-709 Fibro-inflammatory Stromal Cells Produce Atrophy-inducing Paracrine Factors in a Mouse model of Diabetes-associated Sarcopenia

   ENDO 2025 abstract·Oct 22, 2025

2. Diet-induced obesity activates AGE–RAGE signalling in mice.

   “scRNA-seq of gastrocnemius FAPs demonstrated increased advanced glycation end-product (AGE) signaling”

   Animals12-month diet-induced obesitygastrocnemius12 months

   Fibro-inflammatory Stromal Cells Produce Atrophy-Inducing Paracrine Factors in a Mouse Model of Diabetic Sarcopenia

   ADA Scientific Sessions 2025 abstract·Jun 13, 2025

More on AGE–RAGE signalling

1. Diet-induced obesity impairs contractile force in mice.

   “reduced muscle mass, cross-sectional area (CSA), contractile force, and myofiber size.”

   Animalslimb muscle12 months

   MON-709 Fibro-inflammatory Stromal Cells Produce Atrophy-inducing Paracrine Factors in a Mouse model of Diabetes-associated Sarcopenia

   ENDO 2025 abstract·Oct 22, 2025

2. Diet-induced obesity impairs contractile force in mice.

   “reduced muscle mass, cross-sectional area (CSA), contractile force, and myofiber size.”

   Animals12-month diet-induced obesity (DIO) protocol beginning at 2-months oldskeletal muscle12 months

   Fibro-inflammatory Stromal Cells Produce Atrophy-Inducing Paracrine Factors in a Mouse Model of Diabetic Sarcopenia

   ADA Scientific Sessions 2025 abstract·Jun 13, 2025

1. Diet-induced obesity decreases muscle mass in mice.

   “12-month DIO mice developed limb muscle atrophy, as indicated by reduced muscle mass, cross-sectional area (CSA), contractile force, and myofiber size.”

   Animalslimb muscle12 months

   MON-709 Fibro-inflammatory Stromal Cells Produce Atrophy-inducing Paracrine Factors in a Mouse model of Diabetes-associated Sarcopenia

   ENDO 2025 abstract·Oct 22, 2025

2. Diet-induced obesity decreases muscle mass in mice.

   “12-month DIO mice developed limb muscle atrophy, as indicated by reduced muscle mass, cross-sectional area (CSA), contractile force, and myofiber size.”

   Animals12-month diet-induced obesity (DIO) protocol beginning at 2-months oldskeletal muscle12 months

   Fibro-inflammatory Stromal Cells Produce Atrophy-Inducing Paracrine Factors in a Mouse Model of Diabetic Sarcopenia

   ADA Scientific Sessions 2025 abstract·Jun 13, 2025

1. Diet-induced obesity increases THBS1 in mice.

   “emergence of “fibro-inflammatory” sub-populations enriched in transcripts encoding IL6 and thrombospondin-1 (THBS1)”

   Animals12-month diet-induced obesitygastrocnemius12 months

   Fibro-inflammatory Stromal Cells Produce Atrophy-Inducing Paracrine Factors in a Mouse Model of Diabetic Sarcopenia

   ADA Scientific Sessions 2025 abstract·Jun 13, 2025

More on THBS1

1. Diet-induced obesity increases aortic wall thickness in O. aries.

   “Paraffin-embedded fetal aorta section staining revealed increased collagen:elastin ratio and greater aortic wall thickness in OBF1 fetuses.”

   Animalsaorta

   Cardiovascular consequences of maternal obesity throughout the lifespan in first generation sheep

   PloS one·Sep 2, 2022