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Swimming exercise + diet control

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

5

GNRH1

upin mice1

1 study

  1. Swimming exercise + diet control increases GNRH1 in mice.

    “raising secretion of GnRH in the hypothalamus”

    Animalshigh-fat diet ApoE-/- micehypothalamus12-week

    The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression

    Aging9 Jun 2020

More on GNRH1

NF-κB signalling

downin mice1

1 study

  1. Swimming exercise + diet control inhibits NF-κB signalling in mice.

    “inhibiting the expression of NF-κB and raising secretion of GnRH in the hypothalamus”

    Animalshigh-fat diet ApoE-/- micehypothalamus12-week

    The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression

    Aging9 Jun 2020

More on NF-κB signalling

SIRT1

upin mice1

1 study

  1. Swimming exercise + diet control increases SIRT1 in mice.

    “increasing expression of SIRT1, inhibiting the expression of NF-κB and raising secretion of GnRH in the hypothalamus”

    Animalshigh-fat diet ApoE-/- micehypothalamus12-week

    The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression

    Aging9 Jun 2020

More on SIRT1

Learning and memory impairment

downin mice1

1 study

  1. Swimming exercise + diet control decreases learning and memory impairment in mice.

    “hypothalamic inflammation, glial cells activation and learning and memory impairment were effectively alleviated by swimming exercise plus diet control”

    Animalshigh-fat diet ApoE-/- micehypothalamus12-week

    The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression

    Aging9 Jun 2020

Hypothalamic inflammation

downin mice1

1 study

  1. Swimming exercise + diet control decreases hypothalamic inflammation in mice.

    “hypothalamic inflammation, glial cells activation and learning and memory impairment were effectively alleviated by swimming exercise plus diet control”

    Animalshigh-fat diet ApoE-/- micehypothalamus12-week

    The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression

    Aging9 Jun 2020

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