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Dibutyl phosphate

Dibutyl phosphate has been studied in 6 papers since 2022: 6 observational studies in people; 2 in the past year. The newest story, Nov 1, 2026: “Urine marker linked to muscle loss in middle-aged and older US adults”.

Intervention

6 papers study it6 findingsUpdated

PubChemChEBI

1 new paper in 30 daysSee all 6

“negative association was observed between Ln DBUP and the DSST score”
Association between exposure to organophosphate esters and cognitive function in older adults in the United States: NHANES 2011-2014BMC geriatrics2025doi:10.1186/s12877-025-05841-9

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 5 independent labs in 1 country
  • Funders: National Natural Science Foundation of China and 5 more
  • Humans6

What did studies of Dibutyl phosphate find?

1

Studies of Dibutyl phosphate measured 1 outcome; the most studied are cognitive function (1 study).

Cognitive function

downin humans1OR 1.1

1 study

  1. Dibutyl phosphate is linked with worse cognitive function in humans (adjusted logistic regression) (adjusted OR 1.10, 95% CI 1.01-1.20).

    “DBP (adjusted OR: 1.10, 95 % CI: 1.01-1.20) were positively associated with lower cognitive functions”

    Humansadjusted logistic regressionurine

    Association between organophosphorus flame retardants exposure and cognitive impairment among elderly population in southern China

    The Science of the total environment

What is Dibutyl phosphate linked with?

4

Studies link Dibutyl phosphate with 4 measures, most often sarcopenia (2 studies), sarcopenic obesity (1) and cardiovascular disease (1).

Sarcopenia

upin humans2

2 studies

  1. Dibutyl phosphate is associated with sarcopenia in humans.

    “Urinary dibutyl phosphate (DBuP) was positively associated with both sarcopenia and sarcopenic obesity.”

    Humans

    Urine marker linked to muscle loss in middle-aged and older US adults

    BMC public health

  2. Dibutyl phosphate is linked with a higher risk of sarcopenia in humans.

    “two specific urinary metabolites, Dibutyl phosphate (DBUP) and Bis (2-chloroethyl) phosphate (BCEP), were positively correlated with an increased risk of sarcopenia.”

    Humansurine

    Association between exposure to organophosphate esters metabolites and sarcopenia prevalence: A cross-sectional study using NHANES data

    Ecotoxicology and environmental safety

More on Sarcopenia

Sarcopenic obesity

upin humans1

1 study

  1. Dibutyl phosphate is associated with sarcopenic obesity in humans.

    “Urinary dibutyl phosphate (DBuP) was positively associated with both sarcopenia and sarcopenic obesity.”

    Humans

    Urine marker linked to muscle loss in middle-aged and older US adults

    BMC public health

More on Sarcopenic obesity

Cardiovascular disease

upin humans1

1 study

  1. Dibutyl phosphate is linked with a higher risk of cardiovascular disease in humans.

    “Adjusted regression models revealed significant positive associations between urinary bis (2-chloroethyl) phosphate (BCEP) and dibutyl phosphate (DBP) with CVD risk.”

    Humansurine

    Integrating NHANES and network toxicology to assess the impact of organophosphate flame retardants on cardiovascular disease

    Toxicology mechanisms and methods

More on Cardiovascular disease

Cognitive function

downin humans1

1 study

  1. Dibutyl phosphate is associated with cognitive function in humans.

    “negative association was observed between Ln DBUP and the DSST score”

    Humans

    Association between exposure to organophosphate esters and cognitive function in older adults in the United States: NHANES 2011-2014

    BMC geriatrics

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 02 papers in 12 months
BMC Public Health

Urine marker linked to muscle loss in middle-aged and older US adults

An observational analysis of US survey data from 2011–2018 found links to sarcopenia and sarcopenia with obesity, with stronger associations in older adults.An observational analysis of US survey data from 2011–2018 found links to sarcopenia and sarcopenia with obesity, with stronger associations in older adults.

Cross-sectional studyMuscle
Paper

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